The Plaza New York Welcomes 111SKIN: A New Era of Wellness in Luxury Hotels

In the heart of Manhattan, where Fifth Avenue meets Central Park, The Plaza Hotel unveils a new chapter in wellness and refinement with the opening of the 111SKIN Spa/Clinic — the brand’s first exclusive U.S. location.

The partnership brings together two icons of sophistication: The Plaza, a symbol of timeless New York glamour, and 111SKIN, the British skincare brand revered for merging scientific precision with indulgent luxury.

This 8,000-square-foot sanctuary embodies the evolution of luxury hotels, where wellness is no longer an amenity but a central part of the guest experience. For the world’s Ultra High Net Worth Individuals (UHNWIs) — who now represent more than 426,000 individuals globally with a combined wealth exceeding $51 trillion — longevity, rejuvenation, and personalized wellness have become defining priorities of their lifestyle.

A Scientific Approach to Beauty

Inspired by 111SKIN’s origins on Harley Street in London, the Spa/Clinic introduces a concept that fuses clinical-grade skincare innovation with spa-level serenity. Each treatment is designed to deliver measurable, visible results while maintaining the sense of escape The Plaza is known for.

Among the spa’s signature offerings is the Exosome Regenerative Facial, a next-generation treatment combining microdermabrasion, LED therapy, and exosome technology to stimulate cellular repair and renewal. Additional services such as the Reparative Longevity Facial and the Black Diamond Non-Surgical Lift integrate science-backed formulations with 111SKIN’s signature artistry, redefining how beauty and wellness intersect.

Every treatment is personalized — from diagnosis to recovery — reflecting a shift in global hospitality toward experiential wellness. According to Bain & Company’s 2025 Luxury Market Report, over 65% of affluent travelers now seek hotels that integrate wellness and longevity programs as part of their stay.

The Plaza Legacy Meets Modern Longevity

Since 1907, The Plaza has epitomized the grandeur of luxury hotels, hosting world leaders, visionaries, and cultural icons. With the introduction of 111SKIN, the hotel continues to evolve, seamlessly blending its storied heritage with contemporary innovation.

For Sam Ioannidis, The Plaza’s Managing Director, this collaboration is a natural progression. “By uniting innovation in longevity with our legacy of glamour, we’re redefining what wellness means at The Plaza,” he shared. This partnership positions the hotel not merely as a place to stay but as a destination for holistic living in the city that never sleeps.

The design of the spa mirrors 111SKIN’s aesthetic: sleek, modern, and restorative. Serene treatment rooms, curated relaxation lounges, and private consultation areas echo the hotel’s refined interiors, creating an atmosphere where science meets serenity.

Redefining Wellness for the 1%

The opening of 111SKIN at The Plaza reflects a broader evolution within the luxury hotel industry, where personalization and performance are paramount. Today’s UHNW travelers expect more than pampering — they seek measurable outcomes, exclusive access, and experiences that align with their pursuit of longevity and peak vitality.

This growing demand for science-driven wellness has transformed the spa into a new frontier for hospitality innovation. For 111SKIN co-founder Dr. Yannis Alexandrides, The Plaza is the ideal platform to bring this vision to life. “It’s a privilege to call The Plaza Hotel our home in New York. Our goal is to merge advanced skincare with an elevated lifestyle experience,” he said.

A Sanctuary of Modern Luxury

The Plaza’s new 111SKIN Spa/Clinic redefines what it means to retreat in the city. Guests are invited to embark on a fully personalized wellness journey that unites clinical expertise, sensory pleasure, and timeless elegance.

In a world where time is the ultimate luxury, this partnership speaks directly to the 1% — those who value transformation, longevity, and artistry in equal measure. With its fusion of heritage and innovation, The Plaza Hotel once again stands at the vanguard of luxury hotels, setting a new global benchmark for urban wellness destinations.